第11回 杉山特別研究室(理研)公開シンポジウム

テーマ:“Prediction of complex drug-drug interactions, pharmacogenomics and our attempts on virtual clinical studies”

 

 

日時:2018年2月23日(金) 10:00-16:45

会場:理化学研究所横浜事業所 交流棟ホール Access

言語:英語
参加費:シンポジウム 無料

    意見交換会 3000円 ※2月22日(木) 18:00-19:55

 

 

盛会に終了致しました。

多くの方々のご参加ありがとうございました。

 

 

This Symposium is a part of the RIKEN Symposium Series.

【プログラム】

THE 11th RIKEN SYMPOSIUM.pdf
PDFファイル 179.1 KB

10:00-10:10

 

 

Opening remarks
Yuichi Sugiyama (Sugiyama Laboratory, RIKEN Innovation Center)

 

10:10-11:00

 

 

 

【Plenary lecture】
Applying Recent Advances in ADME Science to Enable Drug Design and Clinical Development
Tremaine, Larry M (Pfizer Inc.)

11:00-11:35

 

 

Successes and challenges with small-molecule proteasome inhibitor drugs: Insights for their pharmacokinetics and strategies for moving forward
Wooin Lee (Seoul National University / RIKEN)
11:35-11:50 Break

11:50-12:25

 

 

Kinetic consideration of OATP contribution to drug disposition based on extended clearance concept: Insight to genetic and ethnic variability and drug-drug interaction
Yoshiko Tomita (Sumitomo Dainippon Pharma Co., Ltd.)

12:25-13:35

Lunch Break

13:35-14:10

 

 

Comparative assessment of efficacy and safety of statins based on exposure-response relationship and approach to virtual clinical study.
Yuki Iwaki (Janssen Pharmaceutical Companies of Johnson & Johnson)

14:10-14:45

 

 

Predicting complex DDIs related to CYP induction and OATP inhibition by PBPK model of rifampicin with its own hepatic uptake and auto-induction
Ryuta Asaumi (Ono Pharmaceutical Co., Ltd.)

14:45-15:20

 

 

Application of PBPK modeling to renal OCT2 and MATEs mediated DDIs: Predicting changes in renal clearance and blood AUC caused by the transporter inhibitors
Kotaro Nishiyama (Nippon Boehringer Ingelheim Co., Ltd.)
15:20-15:40 Coffee Break

15:40-16:15

 

 

PBPK analysis of nonlinear pharmacokinetics of taxanes; Role of hepatic uptake transporters, plasma protein binding and pharmaceutical excipients
Nora Lee (Daewoong Pharmaceutical Co., Ltd. / RIKEN)

16:15-16:45

 

General Discussion
Yuichi Sugiyama (Sugiyama Laboratory, RIKEN Innovation Center)

【問い合わせ先】

第11回 杉山特別研究室(理研)公開シンポジウム事務局

TEL 045-503-9210    FAX  045-503-9190
Email:yslab.secretary [ at ] ml.riken.jp ※[at]を@に変えてください。
受付時間:9:30~17:20(土・日・祝祭日 休み)