第16回 杉山特別研究室 理研 公開シンポジウム

テーマ:“Challenges and Opportunities of New Concepts and Tools for predicting
       drug clearance, interindividual differences and drug interactions”
       --- On the occasion of Yuichi Sugiyama’s Retirement from RIKEN---

 

 

日時: 2020年11月16日(月) 13:00-17:15
        2020年11月17日(火)  9:30-17:10
会場: 理化学研究所横浜キャンパス 交流棟ホール
言語: 英語
参加費: 無料

主催:理化学研究所 バトンゾーン研究推進プログラム 杉山特別研究室

共催:東京大学大学院薬学系研究科 分子薬物動態学教室

協賛:薬物動態談話会、創剤フォーラム、CBI学会

 

盛会に終了致しました。

ご参加いただき誠にありがとうございました。

 

 

* オンラインではなく、現地開催となります。
* 海外の講演者につきましては、オンラインでの講演となります。
* 新型コロナウィルス感染症対策として演者を含めて50名以下で開催します。

   お申込受付は先着順とし、定員になり次第、締め切ります。

 

This Symposium is a part of the RIKEN Symposium Series.

【プログラム】

THE_16th_RIKEN_SYMPOSIUM.pdf
PDFファイル 212.9 KB

Day1: November 16th , 2020
13:00-13:10    Opening remarks
                       Kazuya Maeda (The University of Tokyo, Japan / RIKEN)

13:10-13:45   【Keynote Lecture 1】 Web
                       IVIVE: Evaluating the Boundary Conditions.
                       Leslie Z. Benet (University of California, San Francisco, U.S.A.)

13:45-14:20   【Keynote Lecture 2】 Web
                       Deorphaning Transporters in the SLC22 Family: Implications for interindividual

                       variation in drug response.
                       Kathleen M. Giacomini (University of California, San Francisco, U.S.A.)

14:20-14:45     Advances in the endogenous biomarkers for transporter-mediated drug drug interaction

                       risk assessment.
                       Hiroyuki Kusuhara (The University of Tokyo, Japan / RIKEN)

14:45-15:10     Web
                       Shedding light on in vivo target occupancy via PBPK Modeling with saturable target

                       binding: the cases of small-molecule drugs with high-affinity targets.
                       Wooin Lee (Seoul National University, Korea / RIKEN)

15:10-15:35    Coffee break

15:35-16:00    Characterization of the intestinal transport of drugs with human-derived tissue samples.
                       Kazuya Maeda (The University of Tokyo, Japan / RIKEN)

16:00-16:35   【Keynote Lecture 3】 Web
                       Reflections on clearance.
                       Malcolm Rowland (University of Manchester, UK)

16:35-17:10   【Keynote Lecture 4】 Web
                       Liquid Biopsy Enables Quantification of Hepatic Capacity for Drug Metabolism and

                       Disposition beyond the Impact of Genetics.
                       Amin Rostami-Hodjegan (University of Manchester, UK)

17:10-17:15    Closing remark and a note for banquet
                       Kazuya Maeda (The University of Tokyo, Japan / RIKEN)    


Day2: November 17th , 2020
9:30-9:55        My research progress over the last 8 years and Perspective:
        ~ Endeavor continues from the UOT, RIKEN to JIU ~
                      Yuichi Sugiyama (Sugiyama Laboratory, RIKEN, Japan)

9:55-10:30    【Keynote Lecture 5】 Web
                      Regulatory perspective on clinical pharmacology strategy for drug development.
                      Shiew-Mei Huang (U.S. Food and Drug Administration, U.S.A.)

10:30-11:05  【Keynote Lecture 6】 Web
                      Meeting the challenges in quantitating individual clearance pathways by reaction

                      phenotyping.
                      R. Scott Obach (Pfizer Inc., U.S.A.)

11:05-11:30    Web
                      Evaluation of a clinical microdose cocktail to study transporter and CYP3A-mediated

                      DDIs: from healthy subjects to renal impaired patients
                      Xiaoyan Chu (Merck Sharp & Dohme Corp., U.S.A.)

11:30-11:55    Web
                      Use of transporter endogenous biomarker to elucidate the mechanisms of complex DDIs

                      and to support concomitant medication recommendations.
                      Kenta Yoshida (Genentech, Inc., U.S.A.)

11:55-12:50     Lunch

12:50-13:15    Web
                      Contribution of Xenobiotic Transporters to Clinical Pharmacokinetics
                      Jasminder Sahi (Sanofi K.K., China)

13:15-13:40    Comprehensive PBPK Model of Rifampicin for Predicting Complex Drug-drug Interactions:

                      Induction and Inhibition Effects for Metabolic Enzymes and Transporters.
                      Ryuta Asaumi (Ono Pharmaceutical Co., Ltd., Japan)

13:40-14:05    Demonstration of the mechanism underlying the time-dependent inhibition of Cyclosporin

                      A on OATP1B1, and development of the PBPK model of CsA incorporating the time-

                      dependent inhibition.
                      Saki Izumi (Eisai Co., Ltd., Japan)

14:05-14:30    Multiple parameter optimization of PBPK and QSP models using Cluster Gauss-Newton

                      method.
                      Kota Toshimoto (Astellas Pharma Inc., Japan / RIKEN)

14:30-14:50    Coffee break

14:50-15:15    Prediction of unbound brain and CSF drug concentrations in animals and human
                      -Theoretical and empirical approaches for species differences in P-gp and BCRP-
                      Hideki Hirabayashi (Takeda Pharmaceutical Company Limited, Japan)

15:15-15:40    Prediction of renal clearance and plasma pharmacokinetics of opioids using a

                      microphysiological system.
                      Tomoki Imaoka (DAIICHI SANKYO COMPANY, LIMITED, Japan)

15:40-16:05    To what extent can the albumin-mediated transport mechanism bridge the gap of hepatic

                      uptake parameters between in vitro and in vivo?
                      Seiji Miyauchi (Toho University, Japan / RIKEN)

16:05-16:30    Quantitative proteomics for transporters.
                      Sumio Ohtsuki (Kumamoto University, Japan / RIKEN)

16:30-16:55    Transporter-mediated drug disposition in non-injured organs in diseased condition.
                      Yukio Kato (Kanazawa University, Japan / RIKEN)

16:55-17:10    Closing remarks
                      Takashi Yoshikado (Yokohama University of Pharmacy, Japan / RIKEN)

【問い合わせ先】

第16回 杉山特別研究室(理研)公開シンポジウム事務局

TEL 045-503-9210    FAX  045-503-9190
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